Nasopharyngeal carcinoma npc is a squamous cell carcinoma scc arising from the mucosal surface of the nasopharynx. Nov 17, 2016 chan at, teo pm, leung tw, johnson pj. Amyloidosis, nasopharynx, localized, nasopharyngeal carcinoma, congo red stain. Research paper liposometemplated indocyanine green j aggregates for in vivo near infrared imaging and stable photothermal heating calvin c. The nasopharynx represents an intersection between the nasal choanae, the oropharynx, the deep facial spaces, the skull base and the intracranial cavity. Radiotherapy is administered to the gross tumor volume gtv or disease in the primary site and neck adenopathy. Nasopharyngeal carcinoma is the predominant tumor type arising in the nasopharynx, the narrow tubular passage behind the nasal cavity. However, at the close of that study, patients without biopsyproved nasopharyngeal carcinoma nevertheless had shown suspicious. Cancer develops progressively as mutations accumulate. Advances in systemic treatment for nasopharyngeal carcinoma. Veterinary pathology classification and grading of canine. Nasopharyngeal carcinoma in the northeastern states of india. Current systemic treatment for nasopharyngeal carcinoma npc the optimal treatment of npc involves a multidisciplinary approach.
The role of chemotherapy in the management of nasopharyngeal carcinoma. Gu mf, liu lz, he lj, yuan wx, zhang r, luo gy, et al. Thats probably because the nasopharynx isnt easy to examine and symptoms of nasopharyngeal carcinoma mimic those of other, morecommon conditions. The most common form of cancer in the nasopharynx is nasopharyngeal carcinoma npc. Circulating ebv dna in plasma as a cancer biomarker has been studied extensively for the monitoring and prognostication of npc. Nasopharyngeal carcinoma npc is a rare malignancy worldwide, but it is endemic in a few areas including southern china, southeast asia, north africa and the arctic.
Nasopharyngeal carcinoma npc is a prevalent tumour in southern china and southeast asia, particularly in the cantonese population, where its incidence has remained high for decades. The skeletal system was the most common site of distant metastases. The primary role of imaging is accurate tumor mapping and detection of possible tumor extension, especially to the skull base. Epsteinbarr virus ebvencoded rna signal is present in all nasopharyngeal carcinoma. Nasopharyngeal carcinoma is the name of an entity it is not a descriptive term. Lung cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Review article early detection of nasopharyngeal carcinoma.
Extension of nasopharyngeal tumors, especially into the skull base and the deep facial spaces, is well illustrated on imaging. The searchable list includes journal home pages, isnn numbers, and links for browsing journal articles in pubmed. Primary localized amyloidosis in nasopharynx faculty of medicine. His conclusion was that the earliest ct signs of npc were asymmetry and blunting of the for. Nasopharyngeal carcinoma orphanet journal of rare diseases. It differs from other head and neck squamous cell carcinomas in epidemiology, histology, natural history, and response to treatment. Breast cancer research is the highest ranking breast cancerspecific title in the top quartile of oncology journals worldwide.
The initial clinical target volume ctv includes the gtv and all sites of potential subclinical disease to a dose of 4550. Nasopharyngeal carcinoma npc is one of the epsteinbarr virus ebvassociated. Cervical cancer early detection, diagnosis, and staging. Papillomavirus research aims to publish top quality articles, describing innovative research advances in the field of human tumour virology, including epstein barr virus ebv, human t cell leukemia virus htlv, polyoma virus pyv, merkel cell polyomavirus mcpyv, kaposis sarcoma herpes virus kshv and papillomaviruses pv, as well as other related animal tumour virus models. The therapeutic implications of a delayed diagnosis of nasopharyngeal carcinoma npc can be significant. Undetectable tumor cellfree dna in a patient with metastatic breast cancer with complete response and longterm remission view more a collection of tumorspecific websites that cover oncology from every angle for the practicing clinician. Nasopharyngeal carcinoma asian pacific journal of cancer. Since npc is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages. Assessment of retropharyngeal and cervical lymphadenopathy is important for treatment planning. Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern china, and patient prognosis has improved significantly over. In most cases, npc is poorly differentiated and may emerge at any site in the upper respiratory tract. Some early cancers may have signs and symptoms that can be noticed, but thatis not always the case.
Incidence is higher in the chinese and tunisian populations. Incidence of nasopharyngeal carcinoma has remained high in endemic regions. November 2003 journal of cancer research and clinical oncology. Journal of the national comprehensive cancer network. An international journal in cancer research and oncology. Nasopharyngeal carcinoma the journal of laryngology.
Detection of nasopharyngeal carcinoma by mr imaging. However, at the close of that study, patients without biopsyproved nasopharyngeal carcinoma nevertheless had shown suspicious abnormalities on. Nov 17, 2016 radiotherapy is administered to the gross tumor volume gtv or disease in the primary site and neck adenopathy. Nasopharyngeal carcinoma a clinicopathological study in a regional cancer centre of northeastern india. Nasopharyngeal carcinoma is frequent in patients of southern chinese, northern african and alaskan origin. Approximately 70% of patients with npc present with locally advanced disease. The international lung cancer consortium ilcco is an international group of lung cancer researchers, established in 2004 with the aim of sharing comparable data from ongoing lung cancer casecontrol and cohort studies.
Mice with only one allele of the tumor suppressor p53 mutated are not as cancer prone as when both alleles are mutated. Although rare, npc accounts for about one third of childhood nasopharyngeal neoplasms. Nasopharyngeal carcinoma npc is one of the epsteinbarr virus ebv associated. Nasopharyngeal carcinoma npc is a unique disease with a clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head and neck. In hong kong, the incidence rates were estimated to be 21. Lippincott journals subscribers, use your username or email along with your password to log in. Annals of nasopharynx cancermessage from the editorinchief. Breast cancer when you find out you have breast cancer, your doctor will.
Despite the excellent local control with modern radiotherapy, distant failure remains a key. But what is this, how is it classified and who is most at risk. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and. Introduction the geographic incidence of gastric cancer has changed dramatically over the last few decades. Each issue of cancer strives to be comprehensive, spanning the breadth of oncology disciplines and providing something for everyone involved in cancer research, risk reduction, treatment, and. N2 epidemiological trends during the past decade suggest that although incidence of nasopharyngeal carcinoma is gradually declining, even in endemic regions, mortality from the disease has fallen. Patients ages varied from 12 to 72 years old table 1. Nasopharyngeal carcinoma in situ in nasopharyngeal carcinoma. World cancer research journal focused on all areas of cancer. Dietary risk factors for nasopharyngeal carcinoma in. Experimental evidence in mice with either the ras or the myc protooncogenes mutated.
Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Asian paci c journal of cancer prevention, v ol 12, 2011. Npc especially the endemic subtype is a radiosensitive tumor, and as its deepseated anatomic location limits a surgical approach, radiotherapy rt has been the mainstay and primary curative treatment modality. Submissions received later would be considered for next issue of journal. Specifically, it is highly prevalent in southern china, southeast asia, and the middle east. The journal creates a market place for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent. Japan europe north america 0 5 10 15 20 china uk usa india turkey tunisia uganda. The primary role of imaging is accurate tumor mapping and detection of possible tumor extension, especially to the skull. Submit your research before the end of this month to get published in current volume.
Basalcell carcinoma is the most common malignant tumor, and its incidence is increasing. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease. Formalin fixed, paraffin wax embedded biopsy specimens n 285 from 187 patients with npc in 1987 were studied for the presence of cis as well as for the histological assessment of the subtype of cis. Whether you or someone you love has cancer, knowing what to expect can help you cope. From basic information about cancer and its causes to indepth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here. The national comprehensive cancer network nccn, a notforprofit alliance of leading cancer centers devoted to patient care, research, and education, is dedicated to improving the quality, effectiveness, and efficiency of cancer care so that patients can live better lives. The objective of this report is to emphasize that, although rare, nasopharyngeal carcinoma does occur in children and can be diagnosed reliably when. It is with immense pleasure that we launch the inaugural issue of annals of nasopharynx cancera journal dedicated to the sharing of clinical and translational scientific research in nasopharynx cancer. Aug 17, 2018 nasopharyngeal carcinoma is difficult to detect early. Nasopharyngeal carcinoma npc is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. Prolonged survival in a nasopharyngeal carcinoma patient with. Nasopharyngeal carcinoma npc is a unique disease with a clinical presentation, epidemiology.
Mortality from gastric cancer in the united states has declined, perhaps due to dietary. What cancer patients, their families, and caregivers need to know about the coronavirus. Nasopharyngeal carcinoma npc is a rare malignancy in most regions of the world, with a remarkable racial and geographical distribution affecting south china, southeast asia, the maghrebian arabs in north america, and eskimos in the arctic. Cervical cancer early detection, diagnosis, and staging 1. Review of the literature with a focus on therapeutical implications. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 19761985. Mri is commonly used for monitoring patients after therapy. Southern china southeast asia mediterranean alaska rare. Nasopharyngeal carcinoma in situ in nasopharyngeal. Nasopharyngeal carcinoma in children and adolescents a. Breast cancer research and treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. Prolonged survival in a nasopharyngeal carcinoma patient. Surgery choices for dcis are based on how much of the breast has abnormal cells in it and where they are in the breast. Exceptions are the chinese, especially the cantonese living in the central region of guangdong province in southern china.
It is authority to translate published research into text and reference books, worldwide. Elsevier embargo periods are under regular revision and so are subject to change. Hereditary and sporadic pancreatic ductal adenocarcinoma. Nasopharyngeal carcinoma the nasopharynx is the uppermost part of the pharynx upper throat that lies behind the nose. Lee aw, foo w, law sc, poon yf, sze wm, o sk, tung sy, chappell r, lau wh, ho jh. Most nasopharyngeal neoplasms are malignant tumors showing aggressive local infiltration along welldefined routes.
Epsteinbarr virus ebvencoded rna signal is present in all nasopharyngeal carcinoma cells, and early. Short report t cell therapy for nasopharyngeal carcinoma. Questionnaire data from a total of 26000 casecontrol pairs, and the biological samples from the majority of the subjects would be available. To assess the presence of carcinoma in situ cis in patients with nasopharyngeal carcinoma npc and to see if the number of biopsy sites facilitates detection of cis. Prior to 1950, it was the most common cause of cancer death in men, and the third leading cause of cancer death in women in the u. Nasopharyngeal carcinoma npc is a rare malignancy in most parts of the world, with an incidence well under 1 per 100 000 personyears. Recent advances in the management of nasopharyngeal carcinoma. Nasopharyngeal carcinoma npc, although rare in europe and north america, is not uncommon in parts of asia such as southern china and hong kong.
Nasopharyngeal carcinoma journal is recognized as official site for the publication and indexing of research in nasopharyngeal carcinoma. Nasopharyngeal carcinoma radiology reference article. The most common site is the fossa of rosenmuller which is a recess just medial to the medial crura of the eustachian tube. Amyloidosis of the nasopharynx and neck medigraphic. The underlying mechanisms behind this remarkable geographic distribution remain unclear. Nasopharyngeal carcinoma npc is rare in most areas of the world but is much more common in certain populations. Etiology of npc is considered to be related with a complex interaction of environmental and genetic factors as well as epsteinbarr virus infection. Diagnosing the disease in the early stages requires a high index of clinical acumen and, although most crosssectional imaging investigations show the tumour with precision, confirmation is dependent on histology. A cancer journal for clinicians the profile of cancer, globally and by world region, is built up in globocan using the best available sources of cancer incidence and mortality data within a given country. Our previous nasopharyngeal carcinoma detection study, comparing mr imaging, endoscopy, and endoscopic biopsy, showed that mr imaging is a highly sensitive test that identifies nasopharyngeal carcinomas missed by endoscopy. Malaysian journal of medicine and health sciences eissn 26369346. To evaluate the clinical features, treatment results, prognostic factors and late toxicities of nasopharyngeal carcinoma in children and adolescents.
Jun 26, 2006 nasopharyngeal carcinoma npc is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. Nasopharyngeal carcinoma npc has an incidence of 5. Short report t cell therapy for nasopharyngeal carcinoma s basso, m zecca, p merli, a gurrado, s secondino, g quartuccio, i guido, p. Nasopharyngeal carcinoma in young patients johns hopkins. Current management, future directions and dental implications, abstract nasopharyngeal carcinoma npc is a distinct cancer of the head and neck. The patients who developed skeletal metastases were significantly younger than those without skeletal metastases, although there was no difference between sexes.
The chinese journal of cancer recently published an article introducing a new prognostic histopathologic classification of nasopharyngeal carcinoma. Npc is an epsteinbarr virusassociated malignancy with a marked racial and geographic distribution. Within the boundaries of the nasopharynx, the tumour epicentre is frequently seen at the fossa of rosenmuller, from where the tumour invades adjacent anatomical spaces or organs. Consequently, very few oncologists in the western w. Pdf nasopharyngeal carcinoma a clinicopathological. Tumor cell budding from focally disrupted tumor capsules. Nasopharyngeal carcinoma is a cancer arising from the nasopharynx epithelium. Copies of the ebv genome have been found in cells of preinvasive lesions, suggesting that it is directly related to the process of transformation. Treatment for nasopharyngeal carcinoma usually involves radiation therapy, chemotherapy or a combination of the two. Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern china, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Nasopharyngeal carcinoma npc is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Management of nasopharyngeal carcinoma asco journals. Most cases of earlystage disease can be cured by local radiotherapy, with longterm survival 2,3.
The diagnosis protocol used in all patients included. A comprehensive listing of over 250 oncology and related journals. Cervical cancer journal is worlds most read journal in the area of nasopharyngeal carcinoma. The detection of the epsteinbarr virus ebv nuclear antigen and viral dna in nasopharyngeal carcinoma has revealed that ebv can infect epithelial cells and is associated with their malignant transformation. The objective of this report is to emphasize that, although rare, nasopharyngeal carcinoma does occur in children and can be diagnosed reliably when certain key radiographic features are recognized. Extension patterns of nasopharyngeal carcinoma springerlink. Journal specific embargo periods 2019 the following journal specific embargo periods are set to ensure the sustainability of individual journals, and reflect their individual dynamics. Sequential chemoradiotherapy with gemcitabine and cisplatin for locoregionally advanced nasopharyngeal carcinoma. The commonest presenting symptoms were neck swelling 78. Gastric cancer, a joint official journal of the international gastric cancer association and the japanese gastric cancer association, publishes significant studies related to stomach neoplasms. Nasopharyngeal carcinoma accounts for 70% of all primary malignancies of the nasopharynx, and although rare in western populations, it is one of the most common malignancies encountered in asia, especially china 1,35. Nasopharyngeal carcinoma md anderson cancer center.
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